Abstract: The talk will present an alternate measure of information, called Superinformation, which has been found to be very effective for analyzing the coding and noncoding regions of the DNA. In all the previous attempts to analyze the information content of genetic data, Shannon’s entropy (or some variation) has been used. Shannon’s entropy is also called the 'average self-information'. However, as the name suggests, it gives the information content in the average sense, and may not provide the true picture in many cases. This motivates us to first subdivide the sequence to be analyzed into blocks, and then determine the information content of each block. Depending on the particular sequence under evaluation, the different blocks will have different information content (i.e., measure for randomness). Thus there is randomness in the measure for randomness, or in other words, uncertainty of uncertainty! Superinformation is actually a measure of the “randomness of randomness.” It has been found to be highly accurate in classifying coding and noncoding regions of human DNA. In the proposed method, no prior training is required. This technique exhibits higher accuracy than previously reported techniques in distinguishing between the coding and the noncoding portions of the DNA. Superinformation can also be used to analyze the untranslated regions in various genes.
Ranjan Bose received his B.Tech. degree in Electrical Engineering from the Indian Institute of Technology (IIT), Kanpur in 1992 and the M.S. and Ph.D. degrees in Electrical Engineering from the University of Pennsylvania, Philadelphia, USA in 1993 and 1995, respectively. He worked at Alliance Semiconductor Inc., San Jose, as a Senior Design Engineer from 1996 to 1997. Since November 1997 he has been with the department of Electrical Engineering at Indian Institute of Technology, Delhi, where currently he is a Professor. His research interests lie in the areas of Ultra-Wideband (UWB) Communications, Broadband Wireless Access and Coding Theory. He currently heads the Wireless Research Lab in IIT Delhi. Dr. Bose has held guest scientist positions at the Technical University of Darmstadt, Germany, University of Colorado at Boulder, USA and UNIK, Norway. He has published over ninety papers in refereed Journals and Conferences, and has six patents to his credit. He has guided four Ph.D. dissertations and over fifty M.Tech. and B.Tech. projects. His lectures on Wireless Communications form a part of the video courses being offered by the National Program on Technology Enhanced Learning (NPTEL). Dr. Bose is one of the founding members of Virtualwire Technologies, a start-up company incubated within IIT Delhi.
Dr. Bose received the URSI Young Scientist award in 1999, the Humboldt Fellowship in July 2000, the Indian National Academy of Engineers (INAE) Young Engineers Award in 2003 and the AICTE Career Award for Young Teachers in 2004 and the BOYSCAST Fellowship in 2005. He has written a book titled Information Theory, Coding and Cryptography, 2nd Ed. This book has an international edition and has also been translated into Chinese and Korean. He is currently the Editor-in Chief of IETE Journal of Education.